Well it did for me!
I installed Document Examiner and found that it no longer worked. Also all the XML files I open in IE failed to work.
It seems that this is due to a new setting in the IE security model: "Allow active contact to run in files on My Computer" the default is for this to be switched off. By turning this on I've fixed the problem I had with document examiner and XML files. You can find the setting under Tools -> Internet Option -> Advanced, then under the security tab.
Disclaimer: I'm not recommending you switch this on because I have no idea what files you have on your local machine.
I've also switched off Disable Script Debugging (Internet Explorer). I have no idea what the "Other" option does though, maybe this relates to scripts running under cscript.exe?